PAST PROJECTS

Fashion Industries Guild Congenital Heart Laboratory and Hal Kaltman Fashion Industries Guild Congenital Heart Research Endowment​

The Fashion Industries Guild Congenital Heart Laboratory and Hal Kaltman Fashion Industries Guild Congenital Heart Research Endowment is addressing congenital heart defects (the most common type of birth defect nationwide), affecting nearly one percent of U.S. births each year. Even 10 years ago, children born with congenital heart disease faced a future filled with pain from multiple open-heart surgeries, and in some cases, a life expectancy so shortened that they rarely outlived their need for pediatric-based care. Today, medical advances have dramatically prolonged survival for these children, and the Cedars-Sinai Pediatrics Department along with the Heart Institute is working to improve outcomes even further into adulthood. Support for the Laboratory and Research Endowment will advance the study of congenital heart disease and develop more minimally invasive treatments for patients from fetal to advanced age. By improving our capabilities to care for children with congenital heart disease, the need for open heart surgeries at each stage of life might be eliminated.

The Guerin Family Congenital Heart Program, including the Fashion Industries Guild Congenital Heart Laboratory, is taking residence in Cedars-Sinai’s new Advanced Health Sciences Pavilion. Bringing clinics and research labs together under one roof, this state-of-the-art facility is designed to speed medical progress by fostering collaborative links between clinicians and scientists.

The Diana and Steve Marienhoff Fashion Industries Guild Endowed Fellowship in Pediatric Neuromuscular Diseases

This fellowship will directly advance the Department of Pediatrics partnership with the Cedars-Sinai Regenerative Medicine Institute. Their joint quest is to investigate and eventually develop new treatment protocols for a range of devastating neurological diseases affecting children, including but not limited to spinal muscular atrophy, cerebral palsy and epilepsy. By strengthening our ability to fight these illnesses, the fellowship will help children and their families by improving outcomes and offering hope for a healthy and productive future.

The holder of this fellowship is Tyler Pierson, M.D., Ph.D., a pediatric neurologist and expert in pediatric neuromuscular disease.

Kenneth Weinbaum Fashion Industries Guild Pediatric Acute Care Unit

Kenneth Weinbaum Fashion Industries Guild Pediatric Acute Care Unit

The Kenneth Weinbaum Fashion Industries Guild Pediatric Acute Care Unit serves children who do not need to be in Intensive Care but need more care then what is available on the general pediatric floor. This unit will also allow the doctors to work closely with the parents and the child to give them the special training that may be needed when they take their child home.

The Neonatal Intensive Care Wing at Cedars-Sinai

The Neonatal Intensive Care Wing at Cedars-Sinai

The Neonatal Intensive Care Wing at Cedars-Sinai

The Neonatal Intensive Care Unit (NICU) at Cedars-Sinai is a newly constructed, state-of-the-art facility designed to address the needs of critically ill babies, premature newborns and infants requiring close observation.

The NICU is a level III (tertiary) provider of newborn services, which means that it has access to consultants, surgeons and ancillary services that allow treatment across the full range of neonatal problems. It comprises 45 beds in four areas, providing varying levels of care.

Cedars-Sinai's NICU is a designated California Children's Services Regional NICU, and all Cedars-Sinai neonatologists are board-certified, paneled California Children's Services Providers. The NICU is equipped with the latest technology and prepared to provide the highest level of care with the most modern treatment modalities.

As a Level III (tertiary) unit, we take difficult cases that other facilities are not able to handle. The NICU's Neonatal Transport Program moves neonates requiring tertiary care, 24 hours a day, seven days a week, from the referring facility to Cedars-Sinai's NICU.

The NICU employs a highly integrated team of specialists, providing comprehensive diagnostic and therapeutic services, from minimally invasive procedures to complex surgical techniques.

The Ruth Bregman/Fashion Industries Guild Children's Health Clinic

The Ruth Bregman/Fashion Industries Guild Children's Health Clinic provides free and discounted health care to about 4,000 low-income and high-risk children and their families. Our patients are healthy children, children with chronic diseases and children with behavioral and psycho-social problems. They are at particularly high-risk for poor outcomes because of their poverty status as well as the frequent presence of multiple challenges for their families. We provide over 7,500 outpatient clinic visits per year by a skilled team of generalist pediatricians, specialist pediatricians, nurses and social workers. The clinic is also the major training site for CSMC's pediatric residency training program.

Moshe Arditi, MD

GUESS?/Fashion Industries Guild Chair in Community Child Health

Executive Vice-Chair, Department of Pediatrics

Director, Division of Pediatric Infectious Diseases, Allergy and Immunology

Director, Immunologic Diseases Research Center

Moshe Arditi, MD, has made crucial advances made possible by The GUESS?/Fashion

Industries Guild Chair in Community Child Health. We are truly grateful for your longstanding

commitment to this important field of medicine.

Resources provided by GUESS?/Fashion Industries Guild Chair in Community Child Health

continues to support one postdoctoral researcher as well as supplies needed for basic immunology research conducted in the Arditi lab. The data generated has directly helped Dr. Arditi receive two additional new National Institutes of Health (NIH) RO1 grants in the last year from 2017 to 2018, and three new R21 NIH Grant — helping advance this critical research program. Three of the most important achievements over the last year include:

  • Programmatic: Dr. Arditi brought together clinicians and basic science researchers to form a Pediatric – Adult Infectious Disease Academic Group. Since then, the group has started to write papers and apply for grants together. Collaborations like this speed transitions from bench to bed to clinics.

  • Research: The Arditi lab submitted over 15 papers in the last year and 14 of them have already been published. He has submitted four new NIH grants and has been awarded three new NIH grants (1 R21 and 2 new RO1). He also helped two junior faculty in his laboratory receive funding by the NIH: one for an R21 and the other for a new RO1. Two administrative supplements to NIH grants were received in 2018 as Dr. Arditi continues to bring solid NIH indirect funding to the Institution for the 20th year in a row. As the Director of the Infectious and Immunological Research Center (IIDRC) of the Biomedical Science Department, Dr. Arditi is proud to report that his research team is still collectively holding five NIH RO1s and three R21 Awards.

  • Mentoring: Finally, Dr. Arditi continues to mentor a record number of young investigators, physician scientists, fellows and postdocs that he has helped apply and receive NIH and AHA grants. Notably, his senior postdoctoral fellow, Dr. Magali Noval Rivas, received her first AHA grant and her first independent NIH RO1 Award. This last year, he has helped 25 young investigators, with 19 of them receiving grants.

The Smidt Heart Institute at Cedars-Sinai

Eric and Susan Smidt and the Smidt Foundation have established the Smidt Heart Institute with a gift of $50 million—the largest in Cedars-Sinai's 116-year history! This gift will advance vital research and innovative practices in cardiology and cardiovascular surgery. The Smidt Heart Institute brings together 16 Cedars-Sinai centers and programs, including specialization in transplantation, stem cell therapy, women's heart health and hypertension.

"The Smidt Heart Institute will propel us forward in leading the quest for innovation with the goal of devising better treatments for heart disease, one of the world's greatest health needs," said Thomas M. Priselac, president and CEO of Cedars-Sinai.

Tanzania Cardiac Mission

In 2015, Mending Kids deployed the first mission to the Jakaya Kikwete Cardiac Institute (JKCI) in Dar Es Salaam, Tanzania. Over the past few years, we've gone on surgical trips where we performed surgeries as well as training local medical team. This mission provides mentoring and support on complex cases for Dr. Godwin Sharau, the first Tanzanian pediatric cardiac surgeon.

The Mission

  • In 2015, Mending Kids deployed the first mission to the Jakaya Kikwete Cardiac Institute (JKCI) in Dar Es Salaam, Tanzania.

  • This mission is led by Pediatric Interventional Cardiologist Dr. Evan Zahn, from Cedars-Sinai Medical Center in Los Angeles, CA and cardiothoracic surgeon, Dr. Salavatore Agati, from Bambino Gesù Ospedale Pediatrico in Italy.

  • The mission provides mentoring and support on complex cases for Dr. Godwin Sharau, the first Tanzanian pediatric cardiac surgeon and Dr. Naizihjwa Majani, a pediatric cardiologist.

 

The Need

  • Tanzania has a population of nearly 55 million people, 70% of whom live in rural areas with little to no access to medical care.

  • Almost half of the population is under the age of 14, with over 10,000 children in desperate need of life-saving cardiac and life-changing general surgeries.

  • Tanzania requires 90,000 additional healthcare providers to stabilize and address the needs of the current population.

  • Because of their remote locations and lack easy access to care, once a child reaches a Mending Kids mission, their condition has often deteriorated, making their treatments even more complex.

 

Progress and Goals

  • Dr. Zahn, while in Tanzania has also helped children from neighboring countries including Uganda, Kenya and Democratic Republic of Congo. 

  • In 2016, Dr. Sharau trained with Mending Kids on VSDs, Tetralogy of Fallot and performed the first Truncus Arteriosus case (a rare heart defect that must be repaired before 9 months of age) in Tanzania. 

  • Since our last trip, Dr. Sharau and Dr. Majani have performed 100+ life-saving procedures without mission support and are closer to self- sustainment.

  • Through the combined efforts of Dr. Zahn and Dr. Agati, over 80 children have received complex cardiac procedures.